ABOUT

Neuroalgebra is a collaborative project led by the UCL Laboratory of Synaptic Imaging. The dedicated team behind this initiative includes:

• Leonid P. Savtchenko
• Dmitri A. Rusakov

and our long-term industrial collaborators at:

• AMC Bridge LLC (Waltham MA, USA)
• Unboltsoft (Dnipro, Ukraine)
• CyberCurio LLP (Berkhamsted, UK)

To download and explore our computational Tools, please register at Neuroalgebra Forum. For support and suggestions, please consult our Support Page.

Publications reflecting our development and exploration of ARACHNE, ASTRO, and BRAINCELL:

1. Equal levels of pre-and postsynaptic potentiation produce unequal outcomes.
   Savtchenko LP, Rusakov DA.
   Phil Trans Roy Soc B 2024, 379:20230235.

2. Volume-Transmitted GABA Waves Pace Epileptiform Rhythms in the Hippocampal Network.
   Magloire V, Savtchenko LP, T Jensen, S Sylantyev, O Kopach, N Cole, O Tyurikova, D M Kullmann, M C Walker, J S Marvin, LL Looger, JP Hasseman, I Kolb, I Pavlov, Rusakov DA.
   Current Biology 2023, 33:1249-1264.

3. Release probability increases towards distal dendrites boosting high-frequency signal transfer in the rodent hippocampus.
   Jensen TP, Koach O, Reynolds JP, Savtchenko LP, Rusakov DA.
   eLife 2021, 9:62588.

4. Noisy Synaptic Conductance: Bug or a Feature?
   Rusakov DA, Savtchenko LP, Latham P.
   Trends Neurosci. 2020, 43:363-372.

5. Extracellular GABA waves regulate coincidence detection in excitatory circuits.
   Sylantyev S, Savtchenko LP, O’Neill N, Rusakov DA.
   J Physiol. 2020, 598:4047–4062.

6. Disentangling Astroglial Physiology with a Realistic Cell Model in Silico.
   Savtchenko LP, Bard L, Jensen TP, Reynolds JP, Kraev I, Medvedev N, Stewart MG, Henneberger C, Rusakov DA.
   Nat Commun. 2018, 9:3554.

7. ARACHNE: A Neural-Neuroglial Network Builder with Remotely Controlled Parallel Computing.
   Aleksin SG, Zheng K, Rusakov DA, Savtchenko LP.
   PLoS Comput Biol. 2017, 13:e1005467.

8. Tonic GABAA Conductance Bidirectionally Controls Interneuron Firing Pattern and Synchronization in the CA3 Hippocampal Network.
   Pavlov I, Savtchenko LP, Song I, Koo J, Pimashkin A, Rusakov DA, Semyanov A.
   Proc Natl Acad Sci U S A. 2014, 111:504-9.

9. Regulation of rhythm genesis by volume-limited, astroglia-like signals in neural networks
   Savtchenko LP, Rusakov DA.
   Phil Trans Roy Soc B 2014, 369:20130614.